Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ZEB1 (zinc finger E-box binding homeobox 1) Homo sapiens
Symbol: ZEB1
Name: zinc finger E-box binding homeobox 1
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of endothelial cell differentiation and negative regulation of transcription by RNA polymerase II. Localizes to the cytosol and nucleoplasm. Implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AREB6; BZP; delta-crystallin enhancer binding factor 1; DELTA-EF1; DELTAEF1; FECD6; MGC133261; negative regulator of IL2; NIL-2-A; NIL-2A; NIL2A; posterior polymorphous corneal dystrophy 3; PPCD3; TCF8; transcription factor 8 (represses interleukin 2 expression); ZEB; ZFHEP; ZFHX1A; zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein
Mus musculus (house mouse) : Zeb1 (zinc finger E-box binding homeobox 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zeb1 (zinc finger E-box binding homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zeb1 (zinc finger E-box binding homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ZEB1 (zinc finger E-box binding homeobox 1)
Canis lupus familiaris (dog) : ZEB1 (zinc finger E-box binding homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zeb1 (zinc finger E-box binding homeobox 1)
Sus scrofa (pig) : ZEB1 (zinc finger E-box binding homeobox 1)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BW22_H   BW287_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381031,318,417 - 31,529,814 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371031,607,825 - 31,818,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361031,648,148 - 31,856,742 (+)NCBINCBI36hg18NCBI36
Build 341031,648,147 - 31,856,740NCBI
Celera1031,373,372 - 31,583,958 (+)NCBI
Cytogenetic Map10p11.22NCBI
HuRef1031,330,231 - 31,538,974 (+)NCBIHuRef
CHM1_11031,607,376 - 31,818,701 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ZEB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1299953
Created: 2004-06-16
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.