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Gene: Hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8) Rattus norvegicus
Symbol: Hsd17b8
Name: hydroxysteroid (17-beta) dehydrogenase 8
Description: Predicted to have NADH binding activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular hormone metabolic process; fatty acid biosynthetic process; and protein heterotetramerization. Predicted to localize to the mitochondrial envelope; mitochondrial matrix; and plasma membrane. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; androgen antagonist; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; estradiol 17-beta-dehydrogenase 8; Fabgl; KAR alpha subunit; Ke6; MGC109594; RING2; testosterone 17-beta-dehydrogenase 8
Homo sapiens (human) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)  HGNC  Alliance
Mus musculus (house mouse) : H2-Ke6 (H2-K region expressed gene 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Canis lupus familiaris (dog) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
Sus scrofa (pig) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0203,817,212 - 3,819,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,896,543 - 5,898,654 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,964,860 - 4,966,855 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,965,086 - 4,967,082 (+)NCBI
Celera206,426,931 - 6,428,926 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Hsd17b8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1303158
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.