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Gene: Klk1c12 (kallikrein 1-related peptidase C12) Rattus norvegicus
Symbol: Klk1c12
Name: kallikrein 1-related peptidase C12
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to localize to the secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal failure; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glandular kallikrein 12, submandibular/renal; glandular kallikrein-12, submandibular/renal; kallikrein 1; Klk1; Klk12; RSKG-3; tissue kallikrein
No known orthologs. homologs ...
Is Marker For: Strains:   SHRSR.SHRSP-(Klk1-Mt1-ps1)/Bbb   SHRSR.SHRSP-(Klk1-D1Mit3)/Bbb   SHRSP.SHRSR-(Klk1-Mt1-ps1)/Bbb   SHRSP.SHRSR-(Klk1-D1Mit3)/Bbb  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0199,298,965 - 99,303,048 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01100,371,040 - 100,375,077 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,355,758 - 94,359,795 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1194,433,868 - 94,437,906 (-)NCBI
Celera188,645,697 - 88,649,734 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Klk1c12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1303192
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.