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Gene: Sirt5 (sirtuin 5) Rattus norvegicus
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Symbol: Sirt5
Name: sirtuin 5
Description: Predicted to have NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to localize to the cytosol and mitochondrion. Orthologous to human SIRT5 (sirtuin 5); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC93823; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; regulatory protein SIR2 homolog 5; SIR2-like protein 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT5 (sirtuin 5)  HGNC  Alliance
Mus musculus (house mouse) : Sirt5 (sirtuin 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt5 (sirtuin 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT5 (sirtuin 5)
Canis lupus familiaris (dog) : SIRT5 (sirtuin 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt5 (sirtuin 5)
Sus scrofa (pig) : SIRT5 (sirtuin 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01723,986,710 - 24,013,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01725,936,391 - 25,963,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,135,610 - 27,162,715 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11727,138,453 - 27,165,556 (-)NCBI
Celera1721,007,452 - 21,034,513 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Sirt5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1303285
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2019-10-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.