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Gene: Dnmt3a (DNA methyltransferase 3 alpha) Rattus norvegicus
Symbol: Dnmt3a
Name: DNA methyltransferase 3 alpha
Description: Exhibits chromatin binding activity. Involved in several processes, including cellular response to ethanol; hepatocyte apoptotic process; and response to vitamin A. Localizes to cytoplasm and nucleus. Used to study lung carcinoma and middle cerebral artery infarction. Biomarker of congenital heart disease; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndrome; and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha); PARTICIPATES IN DNA modification pathway; methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA methyltransferase 3A; MGC109195
Homo sapiens (human) : DNMT3A (DNA methyltransferase 3 alpha)  HGNC  Alliance
Mus musculus (house mouse) : Dnmt3a (DNA methyltransferase 3A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt3a (DNA methyltransferase 3 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT3A (DNA methyltransferase 3 alpha)
Canis lupus familiaris (dog) : DNMT3A (DNA methyltransferase 3 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt3a (DNA methyltransferase 3 alpha)
Sus scrofa (pig) : DNMT3A (DNA methyltransferase 3 alpha)
Chlorocebus sabaeus (African green monkey) : DNMT3A (DNA methyltransferase 3 alpha)
Heterocephalus glaber (naked mole-rat) : Dnmt3a (DNA methyltransferase 3 alpha)
more info ...
Related Pseudogenes: LOC289651   LOC308670  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0628,205,375 - 28,346,052 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,235,695 - 28,340,577 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,132,683 - 38,149,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0638,044,960 - 38,082,583 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,802,612 - 26,878,878 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1626,805,564 - 26,881,831 (+)NCBI
Celera626,297,300 - 26,371,904 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Dnmt3a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1303336
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.