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Gene: Six5 (SIX homeobox 5) Rattus norvegicus
Symbol: Six5
Name: SIX homeobox 5
Description: Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including lens development in camera-type eye; negative regulation of skeletal muscle satellite cell proliferation; and regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to human SIX5 (SIX homeobox 5); INTERACTS WITH 2,4-dinitrotoluene; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein SIX5; LOC308406; sine oculis-related homeobox 5 homolog; sine oculis-related homeobox 5 homolog (Drosophila)
Homo sapiens (human) : SIX5 (SIX homeobox 5)  HGNC  Alliance
Mus musculus (house mouse) : Six5 (sine oculis-related homeobox 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Six5 (SIX homeobox 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SIX5 (SIX homeobox 5)
Canis lupus familiaris (dog) : SIX5 (SIX homeobox 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Six5 (SIX homeobox 5)
Sus scrofa (pig) : SIX5 (SIX homeobox 5)
Chlorocebus sabaeus (African green monkey) : SIX5 (SIX homeobox 5)
Heterocephalus glaber (naked mole-rat) : Six5 (SIX homeobox 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0180,000,106 - 80,005,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,000,165 - 80,003,232 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,267,384 - 81,272,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,452,076 - 78,455,873 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1178,530,033 - 78,533,385 (+)NCBI
Celera173,207,002 - 73,212,199 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Six5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305040
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.