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Gene: Fto (FTO, alpha-ketoglutarate dependent dioxygenase) Rattus norvegicus
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Symbol: Fto
Name: FTO, alpha-ketoglutarate dependent dioxygenase
Description: Predicted to have DNA-N1-methyladenine dioxygenase activity; demethylase activity; and ferrous iron binding activity. Predicted to be involved in several processes, including mRNA destabilization; nucleic acid metabolic process; and regulation of brown fat cell differentiation. Predicted to localize to cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase); INTERACTS WITH arsenite(3-); bisphenol A; oxaliplatin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity associated; fat mass and obesity-associated protein; LOC291905; m6A(m)-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; RGD1305121; similar to fatso; similar to FTO; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
Orthologs:
Homo sapiens (human) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)  HGNC  Alliance
Mus musculus (house mouse) : Fto (fat mass and obesity associated)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fto (FTO alpha-ketoglutarate dependent dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)
Canis lupus familiaris (dog) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fto (FTO alpha-ketoglutarate dependent dioxygenase)
Sus scrofa (pig) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)
Chlorocebus sabaeus (African green monkey) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)
Heterocephalus glaber (naked mole-rat) : Fto (FTO alpha-ketoglutarate dependent dioxygenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01916,774,549 - 17,115,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,772,744 - 17,115,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01927,803,098 - 28,182,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41916,514,746 - 16,858,800 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11916,517,774 - 16,845,431 (-)NCBI
Celera1915,258,617 - 15,598,740 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Fto
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305121
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.