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Gene: Mars1 (methionyl-tRNA synthetase 1) Rattus norvegicus
Symbol: Mars1
Name: methionyl-tRNA synthetase 1
Description: Predicted to have methionine-tRNA ligase activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to growth factor stimulus; and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Localizes to aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U. Orthologous to human MARS1 (methionyl-tRNA synthetase 1); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC299851; Mars; methionine--tRNA ligase, cytoplasmic; methionine-tRNA synthetase; methionyl-tRNA synthetase
Homo sapiens (human) : MARS1 (methionyl-tRNA synthetase 1)  HGNC  Alliance
Mus musculus (house mouse) : Mars1 (methionine-tRNA synthetase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mars1 (methionyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MARS1 (methionyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : MARS1 (methionyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mars1 (methionyl-tRNA synthetase 1)
Sus scrofa (pig) : MARS1 (methionyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : MARS1 (methionyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Mars1 (methionyl-tRNA synthetase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0770,585,011 - 70,602,425 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,585,013 - 70,602,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,759,159 - 70,776,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,252,510 - 67,269,807 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,273,245 - 67,290,584 (-)NCBI
Celera760,261,413 - 60,278,690 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Mars1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305321
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.