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Gene: Gpt2 (glutamic--pyruvic transaminase 2) Rattus norvegicus
Symbol: Gpt2
Name: glutamic--pyruvic transaminase 2
CRRD ID: 1305462
Description: Predicted to have L-alanine:2-oxoglutarate aminotransferase activity. Involved in several processes, including cellular response to insulin stimulus; positive regulation of gluconeogenesis; and response to testosterone. Localizes to extracellular space and mitochondrion. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alanine aminotransferase 2; ALT2; Cc2-5; glutamic pyruvate transaminase (alanine aminotransferase) 2; glutamic pyruvate transaminase 2; glutamic-pyruvate transaminase 2; LOC307759
Homo sapiens (human) : GPT2 (glutamic--pyruvic transaminase 2)  HGNC  Alliance
Mus musculus (house mouse) : Gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpt2 (glutamic--pyruvic transaminase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GPT2 (glutamic--pyruvic transaminase 2)
Canis lupus familiaris (dog) : GPT2 (glutamic--pyruvic transaminase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpt2 (glutamic--pyruvic transaminase 2)
Sus scrofa (pig) : GPT2 (glutamic--pyruvic transaminase 2)
Chlorocebus sabaeus (African green monkey) : GPT2 (glutamic--pyruvic transaminase 2)
Heterocephalus glaber (naked mole-rat) : Gpt2 (glutamic--pyruvic transaminase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01922,599,003 - 22,633,529 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1922,590,881 - 22,632,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01933,605,445 - 33,644,015 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41922,884,586 - 22,915,553 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11922,889,411 - 22,920,379 (-)NCBI
Celera1921,389,431 - 21,420,291 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gpt2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305462
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.