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Gene: Aak1 (AP2 associated kinase 1) Rattus norvegicus
Symbol: Aak1
Name: AP2 associated kinase 1
Description: Exhibits AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in protein autophosphorylation and regulation of clathrin-dependent endocytosis. Localizes to the cell leading edge; clathrin complex; and terminal bouton. Orthologous to human AAK1 (AP2 associated kinase 1); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adaptor-associated kinase 1; AP2-associated protein kinase 1; LOC312519; LOC500244; RGD1563580; similar to AP2 associated kinase 1
Homo sapiens (human) : AAK1 (AP2 associated kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Aak1 (AP2 associated kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aak1 (AP2 associated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AAK1 (AP2 associated kinase 1)
Canis lupus familiaris (dog) : AAK1 (AP2 associated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aak1 (AP2 associated kinase 1)
Sus scrofa (pig) : AAK1 (AP2 associated kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Aak1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305520
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.