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Gene: Itgb2 (integrin subunit beta 2) Rattus norvegicus
Symbol: Itgb2
Name: integrin subunit beta 2
CRRD ID: 1305581
Description: Contributes to cell adhesion molecule binding activity. Involved in several processes, including endothelial cell migration; leukocyte migration; and regulation of cellular biosynthetic process. Localizes to cell surface and plasma membrane. Predicted to colocalize with cytoplasmic region. Used to study nephritis and pneumonia. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2); PARTICIPATES IN hypoxia inducible factor pathway; integrin mediated signaling pathway; Entamoebiasis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2-nitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cd18; CD18 leukocyte adhesion molecule; integrin beta 2; integrin beta-2; integrin, beta 2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1); integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1, macrophage antigen 1 (mac-1) beta subunit); macrophage antigen 1 (mac-1) beta subunit; macrophage antigen 1 (mac-1) beta subunit); MGC116306
Homo sapiens (human) : ITGB2 (integrin subunit beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Itgb2 (integrin beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb2 (integrin subunit beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB2 (integrin subunit beta 2)
Canis lupus familiaris (dog) : ITGB2 (integrin subunit beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb2 (integrin subunit beta 2)
Sus scrofa (pig) : ITGB2 (integrin subunit beta 2)
Chlorocebus sabaeus (African green monkey) : ITGB2 (integrin subunit beta 2)
Heterocephalus glaber (naked mole-rat) : Itgb2 (integrin subunit beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02011,777,773 - 11,815,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,777,783 - 11,815,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,944,190 - 13,981,048 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,446,521 - 11,485,009 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12011,446,936 - 11,485,236 (-)NCBI
Celera2012,564,941 - 12,601,097 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Itgb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305581
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.