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Gene: Gba2 (glucosylceramidase beta 2) Rattus norvegicus
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Symbol: Gba2
Name: glucosylceramidase beta 2
Description: Predicted to have glucosylceramidase activity; glucosyltransferase activity; and steryl-beta-glucosidase activity. Predicted to be involved in several processes, including glucosylceramide catabolic process; lipid glycosylation; and regulation of protein polymerization. Predicted to localize to cytosol; extrinsic component of organelle membrane; and integral component of membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; beta-naphthoflavone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-glucocerebrosidase 2; beta-glucosidase 2; bile acid beta-glucosidase; bile acid beta-glucosidase GBA2; bile acid glucosyl transferase GBA2; cholesterol glucosyltransferase GBA2; cholesteryl-beta-glucosidase GBA2; glucosidase beta 2; glucosylceramidase 2; LOC298399; NLGase; non-lysosomal glucosylceramidase
Orthologs:
Homo sapiens (human) : GBA2 (glucosylceramidase beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Gba2 (glucosidase beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gba2 (glucosylceramidase beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GBA2 (glucosylceramidase beta 2)
Canis lupus familiaris (dog) : GBA2 (glucosylceramidase beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gba2 (glucosylceramidase beta 2)
Sus scrofa (pig) : GBA2 (glucosylceramidase beta 2)
Chlorocebus sabaeus (African green monkey) : GBA2 (glucosylceramidase beta 2)
Heterocephalus glaber (naked mole-rat) : Gba2 (glucosylceramidase beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0559,068,081 - 59,079,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,068,081 - 59,079,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,592,675 - 63,604,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,045,397 - 60,057,035 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1560,045,575 - 60,057,254 (-)NCBI
Celera556,402,961 - 56,414,599 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Gba2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305598
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.