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Gene: Lrp8 (LDL receptor related protein 8) Rattus norvegicus
Symbol: Lrp8
Name: LDL receptor related protein 8
Description: Exhibits high-density lipoprotein particle binding activity and kinesin binding activity. Involved in several processes, including cellular response to cholesterol; cellular response to growth factor stimulus; and cerebral cortex development. Localizes to several cellular components, including microtubule associated complex; neuronal cell body; and postsynaptic density. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; INTERACTS WITH (+)-schisandrin B; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC362558; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; low-density lipoprotein receptor-related protein 8
Homo sapiens (human) : LRP8 (LDL receptor related protein 8)  HGNC  Alliance
Mus musculus (house mouse) : Lrp8 (low density lipoprotein receptor-related protein 8, apolipoprotein e receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp8 (LDL receptor related protein 8)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP8 (LDL receptor related protein 8)
Canis lupus familiaris (dog) : LRP8 (LDL receptor related protein 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp8 (LDL receptor related protein 8)
Sus scrofa (pig) : LRP8 (LDL receptor related protein 8)
Chlorocebus sabaeus (African green monkey) : LRP8 (LDL receptor related protein 8)
Heterocephalus glaber (naked mole-rat) : Lrp8 (LDL receptor related protein 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05127,404,348 - 127,476,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,404,450 - 127,476,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05131,252,497 - 131,324,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45128,905,612 - 128,975,702 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15128,910,685 - 128,980,029 (+)NCBI
Celera5121,304,991 - 121,373,312 (+)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Lrp8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305729
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.