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Gene: Pink1 (PTEN induced kinase 1) Rattus norvegicus
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Symbol: Pink1
Name: PTEN induced kinase 1
Description: Exhibits protein serine/threonine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hydrogen sulfide; negative regulation of cell death; and positive regulation of mitochondrion organization. Localizes to the growth cone and mitochondrion. Predicted to colocalize with the TORC2 complex and mitochondrial outer membrane translocase complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal recessive early-onset Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1); PARTICIPATES IN mitochondria dynamics pathway; altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC298575; MGC189438; PTEN induced putative kinase 1; serine/threonine-protein kinase PINK1, mitochondrial
Orthologs:
Homo sapiens (human) : PINK1 (PTEN induced kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Pink1 (PTEN induced putative kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pink1 (PTEN induced kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PINK1 (PTEN induced kinase 1)
Canis lupus familiaris (dog) : PINK1 (PTEN induced kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pink1 (PTEN induced kinase 1)
Sus scrofa (pig) : PINK1 (PTEN induced kinase 1)
more info ...
Allele / Splice: Pink1em1Sage  
Genetic Models: LE-Pink1em1Sage-/- LE-Pink1em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05156,677,146 - 156,689,258 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05160,425,715 - 160,437,827 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,091,181 - 157,103,293 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15157,100,712 - 157,113,336 (-)NCBI
Celera5148,924,018 - 148,936,130 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Pink1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1305769
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.