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Gene: Rapgef2 (Rap guanine nucleotide exchange factor 2) Rattus norvegicus
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Symbol: Rapgef2
Name: Rap guanine nucleotide exchange factor 2
Description: Exhibits Rap guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of GTPase activity; and positive regulation of protein phosphorylation. Localizes to several cellular components, including neuron projection; neuronal cell body; and synapse. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2); PARTICIPATES IN adenosine signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2-methoxyethanol; bis(2-chloroethyl) sulfide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CNrasGEF; cyclic nucleotide ras GEF; LOC102553473; LOC310533; neural RAP guanine nucleotide exchange protein; nRap GEP; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Rap guanine nucleotide exchange factor (GEF) 2; rap guanine nucleotide exchange factor 6-like; ras/Rap1-associating GEF-1
Orthologs:
Homo sapiens (human) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Canis lupus familiaris (dog) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
Sus scrofa (pig) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Chlorocebus sabaeus (African green monkey) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Heterocephalus glaber (naked mole-rat) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02177,836,191 - 178,057,378 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2177,836,202 - 178,057,157 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02197,171,946 - 197,285,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42170,472,420 - 170,587,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12170,422,533 - 170,512,880 (-)NCBI
Celera2158,305,258 - 158,419,241 (-)NCBICelera
Cytogenetic Map2q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Rapgef2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1306434
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.