Gene: Map3k5 (mitogen-activated protein kinase kinase kinase 5) Rattus norvegicus
Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Description: Exhibits MAP kinase kinase kinase activity; involved in several processes, including cellular response to tumor necrosis factor, endothelial cell apoptotic process, and positive regulation of cellular metabolic process; localizes to the cytosol and external side of plasma membrane; used to study cerebral infarction and myocardial infarction; biomarker of membranous glomerulonephritis, transient cerebral ischemia, and visual epilepsy; orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5); PARTICIPATES IN p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 4-vinylcyclohexene dioxide; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis signal regulating kinase 1; Ask1; LOC365057; RGD1306565; similar to apoptosis signal-regulating kinase 1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0115,412,603 - 15,613,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0116,961,080 - 17,160,996 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4115,205,361 - 15,346,422 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1115,204,326 - 15,346,541 (+)NCBI
Celera113,127,308 - 13,336,631 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Map3k5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1306565
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.