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Gene: Map2k3 (mitogen activated protein kinase kinase 3) Rattus norvegicus
Symbol: Map2k3
Name: mitogen activated protein kinase kinase 3
CRRD ID: 1306620
Description: Predicted to have MAP kinase kinase activity and protein kinase binding activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Localizes to cytosol. Used to study retinal disease. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 9-cis,11-trans-octadecadienoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen-activated protein kinase kinase 3-like; LOC100911550; LOC303200; Mek3; Mkk3
Homo sapiens (human) : MAP2K3 (mitogen-activated protein kinase kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Map2k3 (mitogen-activated protein kinase kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k3 (mitogen-activated protein kinase kinase 3)
Canis lupus familiaris (dog) : MAP2K3 (mitogen-activated protein kinase kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k3 (mitogen-activated protein kinase kinase 3)
Sus scrofa (pig) : MAP2K3 (mitogen-activated protein kinase kinase 3)
Chlorocebus sabaeus (African green monkey) : MAP2K3 (mitogen-activated protein kinase kinase 3)
Heterocephalus glaber (naked mole-rat) : Map2k3 (mitogen-activated protein kinase kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01045,089,455 - 45,110,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01044,847,090 - 44,868,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,075,270 - 47,096,617NCBIRGSC3.4rn4RGSC3.4
Celera1044,862,946 - 44,884,272 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Map2k3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1306620
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.