Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Map2k3 (mitogen activated protein kinase kinase 3) Rattus norvegicus
Analyze
Symbol: Map2k3
Name: mitogen activated protein kinase kinase 3
Description: Predicted to have MAP kinase kinase activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Localizes to the cytosol. Used to study retinal disease. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 9-cis,11-trans-octadecadienoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen-activated protein kinase kinase 3-like; LOC100911550; LOC303200; Mek3; Mkk3
Orthologs:
Homo sapiens (human) : MAP2K3 (mitogen-activated protein kinase kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Map2k3 (mitogen-activated protein kinase kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k3 (mitogen-activated protein kinase kinase 3)
Canis lupus familiaris (dog) : MAP2K3 (mitogen-activated protein kinase kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k3 (mitogen-activated protein kinase kinase 3)
Sus scrofa (pig) : MAP2K3 (mitogen-activated protein kinase kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01045,089,455 - 45,110,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01044,847,090 - 44,868,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,075,270 - 47,096,617NCBIRGSC3.4rn4RGSC3.4
Celera1044,862,946 - 44,884,272 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Map2k3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1306620
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.