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Gene: Dot1l (DOT1 like histone lysine methyltransferase) Rattus norvegicus
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Symbol: Dot1l
Name: DOT1 like histone lysine methyltransferase
Description: Predicted to have histone methyltransferase activity (H3-K79 specific) and transcription factor binding activity. Predicted to be involved in several processes, including histone H3-K79 methylation; regulation of receptor signaling pathway via JAK-STAT; and regulation of transcription, DNA-templated. Predicted to localize to the nucleoplasm and protein-containing complex. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH (RS)-amphetamine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DOT1-like histone H3K79 methyltransferase; DOT1-like, histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; LOC362831
Orthologs:
Homo sapiens (human) : DOT1L (DOT1 like histone lysine methyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Dot1l (DOT1-like, histone H3 methyltransferase (S. cerevisiae))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dot1l (DOT1 like histone lysine methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DOT1L (DOT1 like histone lysine methyltransferase)
Canis lupus familiaris (dog) : DOT1L (DOT1 like histone lysine methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dot1l (DOT1 like histone lysine methyltransferase)
Sus scrofa (pig) : DOT1L (DOT1 like histone lysine methyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0711,786,105 - 11,824,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,953,820 - 11,992,519 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,428,275 - 10,466,913 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,431,054 - 10,466,674 (-)NCBI
Celera77,100,524 - 7,139,150 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Dot1l
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1306644
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.