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Gene: Mthfs (methenyltetrahydrofolate synthetase) Rattus norvegicus
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Symbol: Mthfs
Name: methenyltetrahydrofolate synthetase
Description: Predicted to have 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in folic acid-containing compound metabolic process and glutamate metabolic process. Predicted to localize to the cytosol and mitochondrial matrix. Orthologous to several human genes including ST20-MTHFS (ST20-MTHFS readthrough); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5, 10-methenyltetrahydrofolate synthetase; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase; LOC300886; MGC95139
Orthologs:
Homo sapiens (human) : MTHFS (methenyltetrahydrofolate synthetase)  HGNC  Alliance
Mus musculus (house mouse) : Mthfs (5, 10-methenyltetrahydrofolate synthetase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mthfs (methenyltetrahydrofolate synthetase)
Canis lupus familiaris (dog) : MTHFS (methenyltetrahydrofolate synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mthfs (methenyltetrahydrofolate synthetase)
Sus scrofa (pig) : LOC102167410 (5-formyltetrahydrofolate cyclo-ligase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0896,564,877 - 96,614,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0896,071,796 - 96,121,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,058,605 - 94,108,277 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1894,078,059 - 94,127,729 (+)NCBI
Celera889,291,095 - 89,340,497 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mthfs
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1306876
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.