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Gene: Frem1 (Fras1 related extracellular matrix 1) Rattus norvegicus
Symbol: Frem1
Name: Fras1 related extracellular matrix 1
Description: Predicted to be involved in cell-matrix adhesion and craniofacial suture morphogenesis. Predicted to localize to basement membrane. Biomarker of congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: INFERRED
Also known as: FRAS1-related extracellular matrix protein 1; LOC298185; RGD1306981; similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2)
Homo sapiens (human) : FREM1 (FRAS1 related extracellular matrix 1)  HGNC  Alliance
Mus musculus (house mouse) : Frem1 (Fras1 related extracellular matrix protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Frem1 (FRAS1 related extracellular matrix 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FREM1 (FRAS1 related extracellular matrix 1)
Canis lupus familiaris (dog) : FREM1 (FRAS1 related extracellular matrix 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Frem1 (FRAS1 related extracellular matrix 1)
Sus scrofa (pig) : FREM1 (FRAS1 related extracellular matrix 1)
Chlorocebus sabaeus (African green monkey) : FREM1 (FRAS1 related extracellular matrix 1)
Heterocephalus glaber (naked mole-rat) : Frem1 (FRAS1 related extracellular matrix 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05101,018,009 - 101,166,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5101,020,448 - 101,166,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05105,039,872 - 105,188,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45101,773,603 - 101,891,178 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15101,778,828 - 102,082,081 (-)NCBI
Celera595,876,081 - 95,993,467 (-)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Frem1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1306981
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.