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Gene: Map2k4 (mitogen activated protein kinase kinase 4) Rattus norvegicus
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Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Description: Exhibits ATP binding activity; JUN kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; cellular response to sorbitol; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including the cytosol; neuron projection; and perikaryon. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in ovarian serous carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ceramide signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dual specificity mitogen-activated protein kinase kinase 4; LOC287398; MAP2K4delta; MKK4; SAPK/ERK kinase 1; Sek1
Orthologs:
Homo sapiens (human) : MAP2K4 (mitogen-activated protein kinase kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Map2k4 (mitogen-activated protein kinase kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k4 (mitogen-activated protein kinase kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K4 (mitogen-activated protein kinase kinase 4)
Canis lupus familiaris (dog) : MAP2K4 (mitogen-activated protein kinase kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k4 (mitogen-activated protein kinase kinase 4)
Sus scrofa (pig) : MAP2K4 (mitogen-activated protein kinase kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01052,196,121 - 52,301,887 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01051,951,707 - 52,054,098 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41052,009,149 - 52,041,599 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11052,020,408 - 52,055,249 (-)NCBI
Celera1049,553,065 - 49,624,419 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Map2k4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307040
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.