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Gene: Map2k4 (mitogen activated protein kinase kinase 4) Rattus norvegicus
Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Description: Exhibits ATP binding activity; JUN kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; cellular response to sorbitol; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including the cytosol; neuron projection; and perikaryon. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in ovarian serous carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ceramide signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
Also known as: dual specificity mitogen-activated protein kinase kinase 4; LOC287398; MAP2K4delta; MKK4; SAPK/ERK kinase 1; Sek1
Homo sapiens (human) : MAP2K4 (mitogen-activated protein kinase kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Map2k4 (mitogen-activated protein kinase kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k4 (mitogen-activated protein kinase kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K4 (mitogen-activated protein kinase kinase 4)
Canis lupus familiaris (dog) : MAP2K4 (mitogen-activated protein kinase kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k4 (mitogen-activated protein kinase kinase 4)
Sus scrofa (pig) : MAP2K4 (mitogen-activated protein kinase kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01052,196,121 - 52,301,887 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01051,951,707 - 52,054,098 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41052,009,149 - 52,041,599 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11052,020,408 - 52,055,249 (-)NCBI
Celera1049,553,065 - 49,624,419 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Map2k4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307040
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.