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Gene: Manf (mesencephalic astrocyte-derived neurotrophic factor) Rattus norvegicus
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Symbol: Manf
Name: mesencephalic astrocyte-derived neurotrophic factor
Description: Predicted to have sulfatide binding activity. Predicted to be involved in neuron differentiation; regulation of response to endoplasmic reticulum stress; and vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Localizes to the extracellular space and perinuclear region of cytoplasm. Colocalizes with the endoplasmic reticulum. Human ortholog(s) of this gene implicated in breast cancer; lung non-small cell carcinoma; pancreatic cancer; renal cell carcinoma; and squamous cell carcinoma. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: arginine-rich protein; arginine-rich, mutated in early stage tumors; Armet; LOC315989
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08115,623,175 - 115,626,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08114,982,000 - 114,985,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,111,358 - 112,113,311 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,129,534 - 112,132,760 (-)NCBI
Celera8106,861,528 - 106,863,481 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Manf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307252
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.