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Gene: Tiam1 (TIAM Rac1 associated GEF 1) Rattus norvegicus
Symbol: Tiam1
Name: TIAM Rac1 associated GEF 1
Description: Exhibits Rac GTPase binding activity; microtubule binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; positive regulation of neurogenesis; and regulation of MAPK cascade. Localizes to several cellular components, including axon; extrinsic component of postsynaptic density membrane; and ruffle membrane. Colocalizes with microtubule. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1
Homo sapiens (human) : TIAM1 (TIAM Rac1 associated GEF 1)  HGNC  Alliance
Mus musculus (house mouse) : Tiam1 (T cell lymphoma invasion and metastasis 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tiam1 (TIAM Rac1 associated GEF 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TIAM1 (TIAM Rac1 associated GEF 1)
Canis lupus familiaris (dog) : TIAM1 (TIAM Rac1 associated GEF 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tiam1 (TIAM Rac1 associated GEF 1)
Sus scrofa (pig) : TIAM1 (TIAM Rac1 associated GEF 1)
Chlorocebus sabaeus (African green monkey) : TIAM1 (TIAM Rac1 associated GEF 1)
Heterocephalus glaber (naked mole-rat) : Tiam1 (TIAM Rac1 associated GEF 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01129,931,083 - 30,061,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,551,577 - 33,681,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,123,752 - 30,252,936 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11130,128,732 - 30,252,936 (+)NCBI
Celera1128,721,403 - 28,849,496 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tiam1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307455
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.