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Gene: Tiam1 (TIAM Rac1 associated GEF 1) Rattus norvegicus
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Symbol: Tiam1
Name: TIAM Rac1 associated GEF 1
Description: Exhibits Rac GTPase binding activity; microtubule binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; positive regulation of neurogenesis; and regulation of MAPK cascade. Localizes to several cellular components, including axon; extrinsic component of postsynaptic density membrane; and ruffle membrane. Colocalizes with microtubule. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1
Orthologs:
Homo sapiens (human) : TIAM1 (TIAM Rac1 associated GEF 1)  HGNC  Alliance
Mus musculus (house mouse) : Tiam1 (T cell lymphoma invasion and metastasis 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tiam1 (TIAM Rac1 associated GEF 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TIAM1 (TIAM Rac1 associated GEF 1)
Canis lupus familiaris (dog) : TIAM1 (TIAM Rac1 associated GEF 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tiam1 (TIAM Rac1 associated GEF 1)
Sus scrofa (pig) : TIAM1 (TIAM Rac1 associated GEF 1)
Chlorocebus sabaeus (African green monkey) : TIAM1 (TIAM Rac1 associated GEF 1)
Heterocephalus glaber (naked mole-rat) : Tiam1 (TIAM Rac1 associated GEF 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01129,931,083 - 30,061,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,551,577 - 33,681,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,123,752 - 30,252,936 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11130,128,732 - 30,252,936 (+)NCBI
Celera1128,721,403 - 28,849,496 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tiam1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307455
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.