Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Lrp1 (LDL receptor related protein 1) Rattus norvegicus
Symbol: Lrp1
Name: LDL receptor related protein 1
CRRD ID: 1307535
Description: Exhibits coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of transport; regulation of cytosolic calcium ion concentration; and regulation of neurogenesis. Localizes to several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; Alzheimer's disease pathway; malaria pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: LOC299858; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; prolow-density lipoprotein receptor-related protein 1
Homo sapiens (human) : LRP1 (LDL receptor related protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Lrp1 (low density lipoprotein receptor-related protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp1 (LDL receptor related protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP1 (LDL receptor related protein 1)
Canis lupus familiaris (dog) : LRP1 (LDL receptor related protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp1 (LDL receptor related protein 1)
Sus scrofa (pig) : LRP1 (LDL receptor related protein 1)
Chlorocebus sabaeus (African green monkey) : LRP1 (LDL receptor related protein 1)
Heterocephalus glaber (naked mole-rat) : Lrp1 (LDL receptor related protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0770,846,313 - 70,927,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,846,344 - 70,926,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,018,808 - 71,099,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,520,575 - 67,601,549 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,541,343 - 67,622,669 (-)NCBI
Celera760,519,175 - 60,599,687 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Lrp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307535
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.