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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of AKIRIN2 mRNA] | CTD | PMID:31150632 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1317188 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AKIRIN2 mRNA | CTD | PMID:22079256 | 1-fluoro-2,4-dinitrobenzene | increases expression | ISO | RGD:1317188 | 6480464 | Dinitrofluorobenzene results in increased expression of AKIRIN2 mRNA | CTD | PMID:23999411 | 17beta-estradiol | increases expression | ISO | RGD:1317188 | 6480464 | Estradiol results in increased expression of AKIRIN2 mRNA | CTD | PMID:19167446 | 2-hydroxypropanoic acid | decreases expression | ISO | RGD:1317188 | 6480464 | Lactic Acid results in decreased expression of AKIRIN2 mRNA | CTD | PMID:30851411 | 3,3',5-triiodo-L-thyronine | increases expression | ISO | RGD:1317188 | 6480464 | Triiodothyronine results in increased expression of AKIRIN2 mRNA | CTD | PMID:23397585 | 4-(ethoxymethylene)-2-phenyloxazol-5-one | increases expression | ISO | RGD:1317188 | 6480464 | Oxazolone results in increased expression of AKIRIN2 mRNA | CTD | PMID:23999411 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of AKIRIN2 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | RGD:1317188 | 6480464 | Aflatoxin B1 results in decreased methylation of AKIRIN2 gene | CTD | PMID:27153756 | arsenous acid | increases expression | ISO | RGD:1317188 | 6480464 | Arsenic Trioxide results in increased expression of AKIRIN2 mRNA | CTD | PMID:22521957 | atrazine | increases expression | ISO | RGD:1317188 | 6480464 | Atrazine results in increased expression of AKIRIN2 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | affects expression | ISO | RGD:1317188 | 6480464 | Benzo(a)pyrene affects the expression of AKIRIN2 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | decreases expression | ISO | RGD:1317188 | 6480464 | Benzo(a)pyrene results in decreased expression of AKIRIN2 mRNA | CTD | PMID:21632981, PMID:26238291 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of AKIRIN2 mRNA | CTD | PMID:25181051 | cadmium atom | increases expression | ISO | RGD:1317188 | 6480464 | Cadmium results in increased expression of AKIRIN2 mRNA | CTD | PMID:23369406 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of AKIRIN2 promoter | CTD | PMID:22457795 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of AKIRIN2 mRNA | CTD | PMID:16278290 | casticin | decreases expression | ISO | RGD:1617911 | 6480464 | casticin results in decreased expression of AKIRIN2 mRNA | CTD | PMID:28444820 | cisplatin | decreases expression | ISO | RGD:1317188 | 6480464 | Cisplatin results in decreased expression of AKIRIN2 mRNA | CTD | PMID:27594783 | cobalt dichloride | increases expression | ISO | RGD:1317188 | 6480464 | cobaltous chloride results in increased expression of AKIRIN2 mRNA | CTD | PMID:19320972 | copper(II) sulfate | increases expression | ISO | RGD:1317188 | 6480464 | Copper Sulfate results in increased expression of AKIRIN2 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | RGD:1317188 | 6480464 | Cyclosporine results in increased expression of AKIRIN2 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:1317188 | 6480464 | Cyclosporine results in decreased expression of AKIRIN2 mRNA | CTD | PMID:21632981 | diarsenic trioxide | increases expression | ISO | RGD:1317188 | 6480464 | Arsenic Trioxide results in increased expression of AKIRIN2 mRNA | CTD | PMID:22521957 | doxorubicin | decreases expression | ISO | RGD:1317188 | 6480464 | Doxorubicin results in decreased expression of AKIRIN2 mRNA | CTD | PMID:29803840 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of AKIRIN2 mRNA | CTD | PMID:29391264 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of AKIRIN2 mRNA | CTD | PMID:24136188 | formaldehyde | increases expression | ISO | RGD:1317188 | 6480464 | Formaldehyde results in increased expression of AKIRIN2 mRNA | CTD | PMID:23649840 | mitomycin C | decreases expression | ISO | RGD:1617911 | 6480464 | Mitomycin results in decreased expression of AKIRIN2 mRNA | CTD | PMID:25270620 | nickel atom | increases expression | ISO | RGD:1317188 | 6480464 | Nickel results in increased expression of AKIRIN2 mRNA | CTD | PMID:24768652, PMID:25583101 | paracetamol | increases expression | ISO | RGD:1317188 | 6480464 | Acetaminophen results in increased expression of AKIRIN2 mRNA | CTD | PMID:21420995, PMID:29067470 | potassium chromate | increases expression | ISO | RGD:1317188 | 6480464 | potassium chromate(VI) results in increased expression of AKIRIN2 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | RGD:1317188 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AKIRIN2 mRNA | CTD | PMID:22079256 | quercetin | decreases expression | ISO | RGD:1317188 | 6480464 | Quercetin results in decreased expression of AKIRIN2 mRNA | CTD | PMID:21632981 | rac-lactic acid | decreases expression | ISO | RGD:1317188 | 6480464 | Lactic Acid results in decreased expression of AKIRIN2 mRNA | CTD | PMID:30851411 | T-2 Toxin | increases expression | EXP | | 6480464 | T-2 Toxin results in increased expression of AKIRIN2 mRNA | CTD | PMID:26141394 | tetrachloroethene | decreases expression | ISO | RGD:1617911 | 6480464 | Tetrachloroethylene results in decreased expression of AKIRIN2 mRNA | CTD | PMID:28973375 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of AKIRIN2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of AKIRIN2 mRNA] | CTD | PMID:31150632 | valproic acid | affects expression | ISO | RGD:1317188 | 6480464 | Valproic Acid affects the expression of AKIRIN2 mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | ISO | RGD:1317188 | 6480464 | Valproic Acid results in decreased methylation of AKIRIN2 gene | CTD | PMID:29154799 | vorinostat | decreases expression | ISO | RGD:1317188 | 6480464 | vorinostat results in decreased expression of AKIRIN2 mRNA | CTD | PMID:27188386 | zoledronic acid | decreases expression | ISO | RGD:1317188 | 6480464 | zoledronic acid results in decreased expression of AKIRIN2 mRNA | CTD | PMID:20977926 | |
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1. | Komiya Y, etal., J Biol Chem. 2008 Jul 4;283(27):18753-64. Epub 2008 May 5. |
2. | RGD automated import pipeline for gene-chemical interactions |
Akirin2 (Rattus norvegicus - Norway rat) |
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AKIRIN2 (Homo sapiens - human) |
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Akirin2 (Mus musculus - house mouse) |
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Akirin2 (Chinchilla lanigera - long-tailed chinchilla) |
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AKIRIN2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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AKIRIN2 (Canis lupus familiaris - dog) |
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Akirin2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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AKIRIN2 (Sus scrofa - pig) |
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RH139650 |
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UniSTS:234891 |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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High | ||||||||||||||||
Medium | 22 | 43 | 23 | 15 | 4 | 3 | 3 | 8 | 26 | 25 | 11 | 11 | 41 | 35 | 8 | 8 |
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Below cutoff |
RefSeq Transcripts | NM_001039914 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_008763614 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AABR07047841 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AAHX01035993 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AAHX01035994 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AB234867 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473962 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001039914 ⟹ NP_001035003 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
CTCAGCCCGAGCGCACGGCGGGGGCGGCCCGGCCTCTCGGGAGCGGCCCCGAGCGGGCGGCGCGhide sequence |
RefSeq Acc Id: | XM_008763614 ⟹ XP_008761836 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
AGGATTTGAATCGGCGGCGTTGTTATTGACGCCATATTGGGGCCGGCGGCGGGTGGCAGAGTTGhide sequence |
Protein RefSeqs | NP_001035003 | (Get FASTA) | NCBI Sequence Viewer |
XP_008761836 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | BAE81786 | (Get FASTA) | NCBI Sequence Viewer |
EDL98593 | (Get FASTA) | NCBI Sequence Viewer | |
Q25C79 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001035003 ⟸ NM_001039914 |
- UniProtKB: | Q25C79 (UniProtKB/Swiss-Prot) |
- Sequence: |
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPhide sequence |
RefSeq Acc Id: | XP_008761836 ⟸ XM_008763614 |
- Peptide Label: | isoform X1 |
- Sequence: |
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPhide sequence |
RGD ID: | 13693616 | |||||||||
Promoter ID: | EPDNEW_R4141 | |||||||||
Type: | initiation region | |||||||||
Name: | Akirin2_1 | |||||||||
Description: | akirin 2 | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1307791 | AgrOrtholog |
Ensembl Genes | ENSRNOG00000008288 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Protein | ENSRNOP00000010962 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Transcript | ENSRNOT00000010962 | ENTREZGENE, UniProtKB/Swiss-Prot |
InterPro | Akirin | UniProtKB/Swiss-Prot |
KEGG Report | rno:297968 | UniProtKB/Swiss-Prot |
NCBI Gene | 297968 | ENTREZGENE |
PANTHER | PTHR13293 | UniProtKB/Swiss-Prot |
PhenoGen | Akirin2 | PhenoGen |
UniGene | Rn.3858 | ENTREZGENE |
UniProt | AKIR2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2008-09-09 | Akirin2 | akirin 2 | RGD1307791 | similar to hypothetical protein FLJ10342 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-04-30 | RGD1307791 | similar to hypothetical protein FLJ10342 | RGD1307791_predicted | similar to hypothetical protein FLJ10342 (predicted) | 'predicted' is removed | 2292626 | APPROVED |
2005-01-20 | RGD1307791_predicted | similar to hypothetical protein FLJ10342 (predicted) | LOC297968_predicted | Symbol and Name status set to approved | 1331353 | APPROVED | |
2005-01-12 | LOC297968_predicted | similar to hypothetical protein FLJ10342 (predicted) | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
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More on Akirin2 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
CRRD Object Information | |
CRRD ID: | 1307791 |
Created: | 2005-01-12 |
Species: | Rattus norvegicus |
Last Modified: | 2019-11-27 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.