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Gene: Gars (glycyl-tRNA synthetase) Rattus norvegicus
Symbol: Gars
Name: glycyl-tRNA synthetase
CRRD ID: 1307856
Description: Predicted to have several functions, including bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; glycine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in diadenosine tetraphosphate biosynthetic process and glycyl-tRNA aminoacylation. Predicted to localize to several cellular components, including axon; extracellular exosome; and secretory granule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Orthologous to human GARS1 (glycyl-tRNA synthetase 1); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; nonketotic hyperglycinemia pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AP-4-A synthetase; ap4A synthetase; diadenosine tetraphosphate synthetase; Gars1; glycine--tRNA ligase; glycyl-tRNA synthetase 1; GlyRS; LOC297113; RGD1559871
Homo sapiens (human) : GARS1 (glycyl-tRNA synthetase 1)  HGNC  Alliance
Mus musculus (house mouse) : Gars (glycyl-tRNA synthetase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gars1 (glycyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GARS1 (glycyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : GARS1 (glycyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gars1 (glycyl-tRNA synthetase 1)
Sus scrofa (pig) : GARS1 (glycyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : GARS1 (glycyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Gars1 (glycyl-tRNA synthetase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0485,235,122 - 85,276,085 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,235,172 - 85,276,044 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,884,600 - 149,933,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,718,584 - 83,759,591 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1484,123,817 - 84,165,539 (-)NCBI
Celera479,038,903 - 79,079,749 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gars
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307856
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.