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Gene: Gars (glycyl-tRNA synthetase) Rattus norvegicus
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Symbol: Gars
Name: glycyl-tRNA synthetase
CRRD ID: 1307856
Description: Predicted to have several functions, including bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; glycine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in diadenosine tetraphosphate biosynthetic process and glycyl-tRNA aminoacylation. Predicted to localize to several cellular components, including axon; extracellular exosome; and secretory granule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Orthologous to human GARS1 (glycyl-tRNA synthetase 1); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; nonketotic hyperglycinemia pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AP-4-A synthetase; ap4A synthetase; diadenosine tetraphosphate synthetase; Gars1; glycine--tRNA ligase; glycyl-tRNA synthetase 1; GlyRS; LOC297113; RGD1559871
Orthologs:
Homo sapiens (human) : GARS1 (glycyl-tRNA synthetase 1)  HGNC  Alliance
Mus musculus (house mouse) : Gars (glycyl-tRNA synthetase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gars1 (glycyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GARS1 (glycyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : GARS1 (glycyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gars1 (glycyl-tRNA synthetase 1)
Sus scrofa (pig) : GARS1 (glycyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : GARS1 (glycyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Gars1 (glycyl-tRNA synthetase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0485,235,122 - 85,276,085 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,235,172 - 85,276,044 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,884,600 - 149,933,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,718,584 - 83,759,591 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1484,123,817 - 84,165,539 (-)NCBI
Celera479,038,903 - 79,079,749 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Gars
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307856
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.