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Gene: Mmp1 (matrix metallopeptidase 1) Rattus norvegicus
Symbol: Mmp1
Name: matrix metallopeptidase 1
Description: Exhibits peptidase activity. Involved in several processes, including cellular response to lipid; female gonad development; and positive regulation of cell migration. Localizes to cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1); PARTICIPATES IN atherosclerosis pathway; endothelin signaling pathway; syndecan signaling pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; alpha-naphthoflavone; benzo[a]pyrene.
Type: protein-coding
Also known as: Clgn; fibroblast collagenase; interstitial collagenase; LOC300339; matrix metallopeptidase 1 (interstitial collagenase); matrix metallopeptidase 1a; matrix metallopeptidase 1a (interstitial collagenase); matrix metalloproteinase 1; matrix metalloproteinase 1a (interstitial collagenase); matrix metalloproteinase-1; MMP-1; Mmp1a; myocardial collagenase
Homo sapiens (human) : MMP1 (matrix metallopeptidase 1)  HGNC  Alliance
Mus musculus (house mouse) : Mmp1a (matrix metallopeptidase 1a (interstitial collagenase))  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : MMP1 (matrix metallopeptidase 1)
Canis lupus familiaris (dog) : MMP1 (matrix metallopeptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp1 (matrix metallopeptidase 1)
Sus scrofa (pig) : MMP1 (matrix metallopeptidase 1)
Chlorocebus sabaeus (African green monkey) : MMP1 (matrix metallopeptidase 1)
Heterocephalus glaber (naked mole-rat) : Mmp1 (matrix metallopeptidase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.085,703,206 - 5,723,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,706,054 - 5,726,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,333,773 - 4,354,284 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,333,814 - 4,353,725 (+)NCBI
Celera86,218,410 - 6,238,921 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Mmp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307917
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.