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Gene: Elane (elastase, neutrophil expressed) Rattus norvegicus
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Symbol: Elane
Name: elastase, neutrophil expressed
Description: Predicted to have several functions, including heparin binding activity; serine-type endopeptidase activity; and transcription corepressor activity. Involved in leukocyte migration involved in inflammatory response and positive regulation of leukocyte tethering or rolling. Predicted to localize to several cellular components, including cell surface; secretory granule; and transcriptional repressor complex. Used to study several diseases, including cerebrovascular disease (multiple); lung disease (multiple); mucositis; pleurisy; and polycythemia vera. Biomarker of suppurative periapical periodontitis. Human ortholog(s) of this gene implicated in cyclic hematopoiesis; periodontitis; severe congenital neutropenia; and severe congenital neutropenia 1. Orthologous to human ELANE (elastase, neutrophil expressed); PARTICIPATES IN systemic lupus erythematosus pathway; INTERACTS WITH amphetamine; anilines; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ela2; elastase 2, neutrophil; LOC299606; neutrophil elastase
Orthologs:
Homo sapiens (human) : ELANE (elastase, neutrophil expressed)  HGNC  Alliance
Mus musculus (house mouse) : Elane (elastase, neutrophil expressed)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ELANE (elastase, neutrophil expressed)
Canis lupus familiaris (dog) : ELANE (elastase, neutrophil expressed)
Sus scrofa (pig) : ELANE (elastase, neutrophil expressed)
Chlorocebus sabaeus (African green monkey) : ELANE (elastase, neutrophil expressed)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0712,638,320 - 12,640,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,638,322 - 12,640,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,808,042 - 12,809,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,329,642 - 11,331,490 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,329,643 - 11,331,467 (-)NCBI
Celera77,992,002 - 7,993,850 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Elane
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307968
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.