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Gene: Herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2) Rattus norvegicus
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Symbol: Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Description: Predicted to have SUMO binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in cellular protein metabolic process; cellular response to DNA damage stimulus; and spermatogenesis. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase HERC2; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2; hect domain and RLD 2; LOC308669; probable E3 ubiquitin-protein ligase HERC2
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01114,453,033 - 114,653,787 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01115,459,325 - 115,658,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41107,440,126 - 107,645,117 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11107,518,956 - 107,722,801 (+)NCBI
Celera1101,115,534 - 101,316,349 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Herc2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1307989
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.