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Gene: Hps4 (HPS4, biogenesis of lysosomal organelles complex 3 subunit 2) Rattus norvegicus
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Symbol: Hps4
Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Description: Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including melanocyte differentiation; melanosome assembly; and protein stabilization. Predicted to localize to BLOC-3 complex; cytoplasmic vesicle; and lysosomal membrane. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 4; and schizophrenia. Orthologous to human HPS4 (HPS4 biogenesis of lysosomal organelles complex 3 subunit 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Hermansky-Pudlak syndrome 4; Hermansky-Pudlak syndrome 4 homolog; Hermansky-Pudlak syndrome 4 homolog (human); LOC304555
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01250,285,239 - 50,315,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1250,285,278 - 50,314,406 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01252,043,358 - 52,072,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41914,326,654 - 14,355,770 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11914,345,603 - 14,357,741 (+)NCBI
Celera1245,847,642 - 45,876,371 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Hps4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308070
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.