Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Apc2 (APC regulator of WNT signaling pathway 2) Rattus norvegicus
Analyze
Symbol: Apc2
Name: APC regulator of WNT signaling pathway 2
Description: Predicted to have beta-catenin binding activity and gamma-catenin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Localizes to the postsynapse. Predicted to colocalize with the cytoplasmic microtubule and filamentous actin. Human ortholog(s) of this gene implicated in Sotos syndrome. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2); PARTICIPATES IN basal cell carcinoma pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; acrylamide.
Type: protein-coding
RefSeq Status: INFERRED
Also known as: adenomatosis polyposis coli 2; adenomatous polyposis coli protein 2; APC2, WNT signaling pathway regulator; LOC299611
Orthologs:
Homo sapiens (human) : APC2 (APC regulator of WNT signaling pathway 2)  HGNC  Alliance
Mus musculus (house mouse) : Apc2 (APC regulator of WNT signaling pathway 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apc2 (APC regulator of WNT signaling pathway 2)
Pan paniscus (bonobo/pygmy chimpanzee) : APC2 (APC regulator of WNT signaling pathway 2)
Canis lupus familiaris (dog) : APC2 (APC regulator of WNT signaling pathway 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apc2 (APC regulator of WNT signaling pathway 2)
Sus scrofa (pig) : APC2 (APC regulator of WNT signaling pathway 2)
Chlorocebus sabaeus (African green monkey) : APC2 (APC regulator of WNT signaling pathway 2)
Heterocephalus glaber (naked mole-rat) : Apc2 (APC regulator of WNT signaling pathway 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0712,258,468 - 12,280,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,258,468 - 12,275,609 (-)Ensembl
Rnor_5.0712,428,263 - 12,450,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,903,675 - 10,920,010 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,906,422 - 10,920,010 (-)NCBI
Celera77,569,129 - 7,585,464 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Apc2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308256
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.