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Gene: Sirt3 (sirtuin 3) Rattus norvegicus
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Symbol: Sirt3
Name: sirtuin 3
Description: Exhibits enzyme binding activity. Involved in aging; negative regulation of cellular metabolic process; and positive regulation of insulin secretion. Localizes to the mitochondrion. Used to study non-alcoholic fatty liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC293615; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIRT3L mitochondrial; sirtuin; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT3 (sirtuin 3)  HGNC  Alliance
Mus musculus (house mouse) : Sirt3 (sirtuin 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt3 (sirtuin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT3 (sirtuin 3)
Canis lupus familiaris (dog) : SIRT3 (sirtuin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt3 (sirtuin 3)
Sus scrofa (pig) : SIRT3 (sirtuin 3)
more info ...
Allele / Splice: Sirt3em25Mcwi   Sirt3em4Mcwi   Sirt3em35Mcwi   Sirt3em30Mcwi  
Genetic Models: SS-Sirt3em25Mcwi T2DN-Sirt3em30Mcwi T2DN-Sirt3em35Mcwi SS-Sirt3em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Celera1193,586,014 - 193,607,810 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sirt3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308374
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.