Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Mttp (microsomal triglyceride transfer protein) Rattus norvegicus
Analyze
Symbol: Mttp
Name: microsomal triglyceride transfer protein
Description: Exhibits apolipoprotein binding activity; lipid transporter activity; and protein heterodimerization activity. Involved in several processes, including cholesterol homeostasis; lipoprotein metabolic process; and response to calcium ion. Localizes to several cellular components, including the basolateral plasma membrane; cell projection membrane; and cytoplasm. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; hyperinsulinism; nonalcoholic fatty liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein); INTERACTS WITH (R)-carnitine; (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: microsomal triglyceride transfer protein large subunit; MTP
Orthologs:
Homo sapiens (human) : MTTP (microsomal triglyceride transfer protein)  HGNC  Alliance
Mus musculus (house mouse) : Mttp (microsomal triglyceride transfer protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mttp (microsomal triglyceride transfer protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MTTP (microsomal triglyceride transfer protein)
Canis lupus familiaris (dog) : MTTP (microsomal triglyceride transfer protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mttp (microsomal triglyceride transfer protein)
Sus scrofa (pig) : MTTP (microsomal triglyceride transfer protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02243,366,181 - 243,407,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02261,907,825 - 261,948,693 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,613,710 - 235,654,848 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12235,600,461 - 235,641,567 (-)NCBI
Celera2218,769,332 - 218,810,411 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mttp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308388
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.