Gene: Nkx2-2 (NK2 homeobox 2) Rattus norvegicus
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Symbol: Nkx2-2
Name: NK2 homeobox 2
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding activity, and nucleic acid binding activity; involved in optic nerve development, response to glucose, and response to progesterone; localizes to the nucleus; biomarker of demyelinating disease; orthologous to human NKX2-2 (NK2 homeobox 2); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: homeobox protein Nkx-2.2; NK2 transcription factor related, locus 2; NK2 transcription factor related, locus 2 (Drosophila)
Orthologs:
Homo sapiens (human) : NKX2-2 (NK2 homeobox 2)  HGNC  Alliance
Mus musculus (house mouse) : Nkx2-2 (NK2 homeobox 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-2 (NK2 homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-2 (NK2 homeobox 2)
Canis lupus familiaris (dog) : NKX2-2 (NK2 homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-2 (NK2 homeobox 2)
Sus scrofa (pig) : NKX2-2 (NK2 homeobox 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03141,408,460 - 141,419,083 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03147,826,697 - 147,837,976 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43135,837,591 - 135,839,963 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13135,742,546 - 135,745,581 (-)NCBI
Celera3133,482,823 - 133,485,195 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Nkx2-2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308443
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.