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Gene: Ctns (cystinosin, lysosomal cystine transporter) Rattus norvegicus
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Symbol: Ctns
Name: cystinosin, lysosomal cystine transporter
Description: Predicted to have L-cystine transmembrane transporter activity. Involved in L-cystine transport; negative regulation of hydrogen peroxide biosynthetic process; and positive regulation of mitochondrial membrane potential. Predicted to localize to the cytoplasm; intermediate filament cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in cystinosis. Orthologous to human CTNS (cystinosin, lysosomal cystine transporter); PARTICIPATES IN cysteine metabolic pathway; mercaptolactate-cysteine disulfiduria pathway; ocular nonnephropathic cystinosis pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cystinosin; cystinosis, nephropathic; LOC287478; similar to Cystinosin
Orthologs:
Homo sapiens (human) : CTNS (cystinosin, lysosomal cystine transporter)  HGNC  Alliance
Mus musculus (house mouse) : Ctns (cystinosis, nephropathic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctns (cystinosin, lysosomal cystine transporter)
Pan paniscus (bonobo/pygmy chimpanzee) : CTNS (cystinosin, lysosomal cystine transporter)
Canis lupus familiaris (dog) : CTNS (cystinosin, lysosomal cystine transporter)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctns (cystinosin, lysosomal cystine transporter)
Sus scrofa (pig) : CTNS (cystinosin, lysosomal cystine transporter)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01059,749,250 - 59,772,475 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01059,488,895 - 59,503,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41060,060,254 - 60,075,352 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11060,074,699 - 60,089,377 (-)NCBI
Celera1056,924,889 - 56,939,979 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Ctns
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308466
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.