Gene: Sirt1 (sirtuin 1) Rattus norvegicus
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Symbol: Sirt1
Name: sirtuin 1
Description: Exhibits NAD-dependent histone deacetylase activity and protein kinase B binding activity; involved in several processes, including cellular response to ketone, negative regulation of cell death, and regulation of peptide transport; localizes to the cytosol, growth cone, and nucleus; predicted to colocalize with the ESC/E(Z) complex; used to study middle cerebral artery infarction, obesity, osteoporosis, and type 2 diabetes mellitus; biomarker of several diseases, including acute kidney failure, artery disease (multiple), epilepsy, impotence, and nonalcoholic fatty liver disease; orthologous to human SIRT1 (sirtuin 1); PARTICIPATES IN histone modification pathway; p53 signaling pathway; RNA polymerase I transcription pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: MODEL
Also known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; Sir2; Sir2alpha; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT1 (sirtuin 1)  HGNC  Alliance
Mus musculus (house mouse) : Sirt1 (sirtuin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt1 (sirtuin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT1 (sirtuin 1)
Canis lupus familiaris (dog) : SIRT1 (sirtuin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt1 (sirtuin 1)
Sus scrofa (pig) : SIRT1 (sirtuin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sirt1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308542
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-05-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.