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Gene: Shmt2 (serine hydroxymethyltransferase 2) Rattus norvegicus
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Symbol: Shmt2
Name: serine hydroxymethyltransferase 2
Description: Exhibits several functions, including L-allo-threonine aldolase activity; anion binding activity; and glycine hydroxymethyltransferase activity. Involved in L-serine biosynthetic process; glycine biosynthetic process from serine; and positive regulation of cell population proliferation. Localizes to mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial matrix. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2); PARTICIPATES IN folate mediated one-carbon metabolic pathway; glycine metabolic pathway; glycine, serine and threonine metabolic pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC299857; MGC105820; serine hydroxymethyl transferase 2 (mitochondrial); serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial
Orthologs:
Homo sapiens (human) : SHMT2 (serine hydroxymethyltransferase 2)  HGNC  Alliance
Mus musculus (house mouse) : Shmt2 (serine hydroxymethyltransferase 2 (mitochondrial))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shmt2 (serine hydroxymethyltransferase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHMT2 (serine hydroxymethyltransferase 2)
Canis lupus familiaris (dog) : SHMT2 (serine hydroxymethyltransferase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shmt2 (serine hydroxymethyltransferase 2)
Sus scrofa (pig) : SHMT2 (serine hydroxymethyltransferase 2)
Chlorocebus sabaeus (African green monkey) : SHMT2 (serine hydroxymethyltransferase 2)
Heterocephalus glaber (naked mole-rat) : Shmt2 (serine hydroxymethyltransferase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0770,824,718 - 70,829,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,824,715 - 70,829,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,998,103 - 71,003,197 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,494,470 - 67,499,540 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,515,199 - 67,520,270 (-)NCBI
Celera760,498,180 - 60,503,250 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Shmt2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308582
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.