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Gene: Neu4 (neuraminidase 4) Rattus norvegicus
Symbol: Neu4
Name: neuraminidase 4
Description: Predicted to have exo-alpha-sialidase activity. Predicted to be involved in ganglioside catabolic process; glycoprotein catabolic process; and oligosaccharide catabolic process. Predicted to localize to the lysosome and organelle inner membrane. Orthologous to human NEU4 (neuraminidase 4); PARTICIPATES IN sphingolipid metabolic pathway; INTERACTS WITH acrylamide; bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
Also known as: LOC316642; sialidase 4; sialidase-4
Homo sapiens (human) : NEU4 (neuraminidase 4)  HGNC  Alliance
Mus musculus (house mouse) : Neu4 (sialidase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Neu4 (neuraminidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NEU4 (neuraminidase 4)
Canis lupus familiaris (dog) : NEU4 (neuraminidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Neu4 (neuraminidase 4)
Sus scrofa (pig) : NEU4 (neuraminidase 4)
Chlorocebus sabaeus (African green monkey) : NEU4 (neuraminidase 4)
Heterocephalus glaber (naked mole-rat) : Neu4 (neuraminidase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: Neu4 (GeneID: 316642) is annotated incorrectly on Rnor_6.0 but correctly on Rn_Celera. Annotation of Neu4 on Rn_Celera is supported by synteny with human and mouse and is instead annotated as NEWGENE_1308624 (GeneID: 103690047) on Rnor_6.0. Additionally, the locus annotated as Neu4 on Rnor_6.0 likely represents a duplicate placement of this locus that lacks support by the syntenic region in mouse and human. BLASTing Neu4 NM_001108234.1 and NEWGENE_1308624 XM_006245535.2 against the rat genome (Annotation Release 105) shows best hits to NC_005108.4 on Rnor_6.0 (at locations where Neu4 and NEWGENE_1308624 are annotated) and AC_000077.1 on Rn_Celera where Neu4 is annotated. 2-sequence BLAST of Neu4 NM_001108234.1 against NEWGENE_1308624 XM_006245535.2 shows high sequence identity (66% coverage, 100% identity). BLASTing Neu4 underlying component AC118069.8 against the rat genome shows best hit to NC_005108.4 on Rnor_6.0 where Neu4 is annotated (hitting itself) and where NEWGENE_1308624 is annotated. 2-sequence BLAST of Neu4 underlying component AC118069.8 against NEWGENE_1308624 underlying component AABR07068355.1 shows 99% sequence identity across ~96 kb. [27 Mar 2015]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.09101,284,902 - 101,290,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,284,902 - 101,290,558 (+)Ensembl
Rnor_5.09100,655,816 - 100,661,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,150,680 - 93,156,336 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1993,343,347 - 93,360,169 (+)NCBI
Celera991,931,048 - 91,936,704 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Neu4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308624
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.