Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Neu4 (neuraminidase 4) Rattus norvegicus
Analyze
Symbol: Neu4
Name: neuraminidase 4
Description: Predicted to have exo-alpha-sialidase activity. Predicted to be involved in ganglioside catabolic process; glycoprotein catabolic process; and oligosaccharide catabolic process. Predicted to localize to the lysosome and organelle inner membrane. Orthologous to human NEU4 (neuraminidase 4); PARTICIPATES IN sphingolipid metabolic pathway; INTERACTS WITH acrylamide; bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC316642; sialidase 4; sialidase-4
Orthologs:
Homo sapiens (human) : NEU4 (neuraminidase 4)  HGNC  Alliance
Mus musculus (house mouse) : Neu4 (sialidase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Neu4 (neuraminidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NEU4 (neuraminidase 4)
Canis lupus familiaris (dog) : NEU4 (neuraminidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Neu4 (neuraminidase 4)
Sus scrofa (pig) : NEU4 (neuraminidase 4)
Chlorocebus sabaeus (African green monkey) : NEU4 (neuraminidase 4)
Heterocephalus glaber (naked mole-rat) : Neu4 (neuraminidase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: Neu4 (GeneID: 316642) is annotated incorrectly on Rnor_6.0 but correctly on Rn_Celera. Annotation of Neu4 on Rn_Celera is supported by synteny with human and mouse and is instead annotated as NEWGENE_1308624 (GeneID: 103690047) on Rnor_6.0. Additionally, the locus annotated as Neu4 on Rnor_6.0 likely represents a duplicate placement of this locus that lacks support by the syntenic region in mouse and human. BLASTing Neu4 NM_001108234.1 and NEWGENE_1308624 XM_006245535.2 against the rat genome (Annotation Release 105) shows best hits to NC_005108.4 on Rnor_6.0 (at locations where Neu4 and NEWGENE_1308624 are annotated) and AC_000077.1 on Rn_Celera where Neu4 is annotated. 2-sequence BLAST of Neu4 NM_001108234.1 against NEWGENE_1308624 XM_006245535.2 shows high sequence identity (66% coverage, 100% identity). BLASTing Neu4 underlying component AC118069.8 against the rat genome shows best hit to NC_005108.4 on Rnor_6.0 where Neu4 is annotated (hitting itself) and where NEWGENE_1308624 is annotated. 2-sequence BLAST of Neu4 underlying component AC118069.8 against NEWGENE_1308624 underlying component AABR07068355.1 shows 99% sequence identity across ~96 kb. [27 Mar 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.09101,284,902 - 101,290,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,284,902 - 101,290,558 (+)Ensembl
Rnor_5.09100,655,816 - 100,661,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,150,680 - 93,156,336 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1993,343,347 - 93,360,169 (+)NCBI
Celera991,931,048 - 91,936,704 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Neu4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308624
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.