 Gene Ontology Annotations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Component
Molecular Function
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Analyze GeneStrainQTL List |
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 Gene Annotator (Annotation Comparison) unavailable |
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Gene Annotator (Annotation Comparison) |
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Cellular Component
Molecular Function
Gene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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References - curated| 1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | MGD data from the GO Consortium |
| 3. | RGD automated data pipeline |
| 4. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 5. | RGD automated import pipeline for gene-chemical interactions |
References - uncuratedGenomics
Comparative Map Data| Nek11 (Rattus norvegicus - Norway rat) |
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| NEK11 (Homo sapiens - human) |
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| Nek11 (Mus musculus - house mouse) |
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| Nek11 (Chinchilla lanigera - long-tailed chinchilla) |
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| NEK11 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| NEK11 (Canis lupus familiaris - dog) |
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| Nek11 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| NEK11 (Sus scrofa - pig) |
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Position Markers| D8Got330 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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| High | ||||||||||||||||
| Medium | 7 | 8 | ||||||||||||||
| Low | 15 | 28 | 23 | 15 | 4 | 3 | 2 | 18 | 25 | 11 | 10 | 39 | 35 | 8 | 8 | |
| Below cutoff | 15 | 2 | 6 | 1 | 2 |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001108182 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_008766530 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595680 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595681 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595682 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595683 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595684 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595685 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595686 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595687 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595688 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595689 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017595690 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07071393 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07071394 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01056877 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01056878 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01056879 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473954 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_001108182 ⟹ NP_001101652 | ||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
TGCCAGAAACGACGTCACTGGGAAGCCTGGCTCGGAGAAGCAGAGGGCTCTTCCTGGAGGGGAAhide sequence |
| RefSeq Acc Id: | XM_008766530 ⟹ XP_008764752 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595680 ⟹ XP_017451169 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595681 ⟹ XP_017451170 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595682 ⟹ XP_017451171 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595683 ⟹ XP_017451172 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595684 ⟹ XP_017451173 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595685 ⟹ XP_017451174 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CTGAGGCTGTCTTTGAACTCCTGATCCTCCTACCTCCACCTTATAACTTCTGGGGTGAGAGGCAhide sequence |
| RefSeq Acc Id: | XM_017595686 ⟹ XP_017451175 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
TGTCTCTTTGACATCTTTTAACAGTGTCATCAGATGGCCTCAAATCATGATATAGCATGACTAAhide sequence |
| RefSeq Acc Id: | XM_017595687 ⟹ XP_017451176 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
GTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGCCGCCAAChide sequence |
| RefSeq Acc Id: | XM_017595688 ⟹ XP_017451177 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595689 ⟹ XP_017451178 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
| RefSeq Acc Id: | XM_017595690 ⟹ XP_017451179 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CGACGATGTTAAACAACCACACCGGTCCAAGCTGTGAGCTTCAGGCTGAGGCTTGGCAGGGCGChide sequence |
Protein Sequences| Protein RefSeqs | NP_001101652 | (Get FASTA) | NCBI Sequence Viewer |
| XP_008764752 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451169 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451170 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451171 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451172 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451173 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451174 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451175 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451176 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451177 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451178 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451179 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | EDL77346 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001101652 ⟸ NM_001108182 |
| - UniProtKB: | D4A3H8 (UniProtKB/TrEMBL) |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_008764752 ⟸ XM_008766530 |
| - Peptide Label: | isoform X10 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451170 ⟸ XM_017595681 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451171 ⟸ XM_017595682 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451169 ⟸ XM_017595680 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451176 ⟸ XM_017595687 |
| - Peptide Label: | isoform X6 |
| - Sequence: |
MEAQLLSTLNHPAIVRFHESFMEQGTFCIITEYCEGRDLDYKIQEYKEAGKIFPDNQIVEWFIQhide sequence |
| RefSeq Acc Id: | XP_017451175 ⟸ XM_017595686 |
| - Peptide Label: | isoform X6 |
| - Sequence: |
MEAQLLSTLNHPAIVRFHESFMEQGTFCIITEYCEGRDLDYKIQEYKEAGKIFPDNQIVEWFIQhide sequence |
| RefSeq Acc Id: | XP_017451174 ⟸ XM_017595685 |
| - Peptide Label: | isoform X6 |
| - Sequence: |
MEAQLLSTLNHPAIVRFHESFMEQGTFCIITEYCEGRDLDYKIQEYKEAGKIFPDNQIVEWFIQhide sequence |
| RefSeq Acc Id: | XP_017451179 ⟸ XM_017595690 |
| - Peptide Label: | isoform X9 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451177 ⟸ XM_017595688 |
| - Peptide Label: | isoform X7 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451172 ⟸ XM_017595683 |
| - Peptide Label: | isoform X4 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451173 ⟸ XM_017595684 |
| - Peptide Label: | isoform X5 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
| RefSeq Acc Id: | XP_017451178 ⟸ XM_017595689 |
| - Peptide Label: | isoform X8 |
| - Sequence: |
MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGhide sequence |
TranscriptomeStrain Variation
Strain Sequence Variants (Rnor 6.0)
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Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 8 | 113228014 | 113228015 | G | A | snv | COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), ACI/N (KNAW), SHR/NHsd (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), LE/OrlBarth (UDEL), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), ZFDM (KyushuU), LH/MavRrrc (KNAW), BBDP/WorN (KNAW), SBN/Ygl (KNAW), SHR/OlaIpcv (KNAW), F344/NRrrc (Illumina) (KNAW), FHH/EurMcwi (KNAW), SDLEF7/Barth (UDEL), IS/Kyo (KyushuU), HWY/Slc (KyushuU), FHL/EurMcwi (MCW), SR/JrHsd (MCW), LN/MavRrrc (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), ACI/EurMcwi (KNAW), SHR/OlaIpcvPrin (KNAW), WKY/NHsd (KNAW), MNS/Gib (KNAW), F344/Stm (KyushuU), MR/N (KNAW), SBH/Ygl (KNAW), GK/Ox (KNAW), LE/Stm (SOLiD) (KNAW), LEW/Crl (KNAW), M520/N (KNAW), LE/Stm (KyushuU), BDIX/NemOda (KyushuU), DOB/Oda (KyushuU), KFRS3B/Kyo (KyushuU), ACI/EurMcwi (MCW), SS/JrHsdMcwi (MCW), LEW/NCrl (KNAW), BUF/MNa (KyushuU), ZF (KyushuU), SBN/Ygl (MCW), MHS/Gib (KNAW), WAG/Rij (KNAW), SHRSP/Gcrc (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), F344/NHsd (KNAW), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), LEC/Tj (KyushuU), FHH/EurMcwi (MCW), SR/JrHsd (KNAW), SHR/NCrlPrin (KNAW), WKY/NCrl (KNAW), FHL/EurMcwi (KNAW), LE/Stm (Illumina) (KNAW), WN/N (KNAW), NIG-III/Hok (KyushuU), F344/Jcl (KyushuU), SBH/Ygl (MCW), LL/MavRrrc (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), Crl:SD (UDEL), HTX/Kyo (KyushuU) |
Assembly: Rnor_6.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 8 | 113842477 | 113842478 | G | A | snv | ACI/EurMcwi (MCW), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW), SBN/Ygl (MCW), CDS, CDR, COP/CrCrl (MCW & UW), SBH/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW) |
Assembly: RGSC_v3.4
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 8 | 110391944 | 110391945 | G | A | snv | BBDP/WorN (ICL), LCR/2Mco (UMich), LEW/Crl (ICL), LH/MavRrrc (ICL), SHR/NHsd (ICL), HCR/2Mco (UMich), DA/BklArbNsi (ICAHN), FHH/EurMcwi (MDC), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), GK/Ox (ICL), SBH/Ygl (ICL), WAG/Rij (ICL), WKY/Gcrc (ICL), LCR/1Mco (UMich), F344/NHsd (ICAHN), SHRSP/Gcrc (MDC), ACI/EurMcwi (MCW), SR/JrHsd (MCW), ACI/EurMcwi (ICL), LL/MavRrrc (ICL), SHRSP/Gcrc (ICL), SS/JrHsdMcwi (MCW), FHL/EurMcwi (ICL), LEW/NCrl (ICL), MNS/Gib (ICL), SBN/Ygl (ICL), SHR/OlaIpcv (ICL), COP/CrCrl (MCW & UW), MHS/Gib (ICL), SS/JrHsdMcwi (MDC), SHR/OlaIpcv (KNAW), LE/Stm (ICL), LN/MavRrrc (ICL), WKY/NHsd (ICL), SHR/OlaIpcv (ICL), M520/N (KNAW), GH/OmrMcwi (MCW), F344/NCrl (ICL), SR/JrHsd (ICL), SS/Jr (ICL), ACI/N (KNAW), SS/JrHsdMcwi (ICL), WKY/NCrl (ICL), HCR/1Mco (UMich), FHH/EurMcwi (ICL) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1308801 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000042432 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000047201 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000046816 | ENTREZGENE, UniProtKB/TrEMBL |
| InterPro | Kinase-like_dom | UniProtKB/TrEMBL |
| Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
| Ser/Thr_prot_kinase_AS | UniProtKB/TrEMBL | |
| KEGG Report | rno:315978 | UniProtKB/TrEMBL |
| NCBI Gene | 315978 | ENTREZGENE |
| Pfam | Pkinase | UniProtKB/TrEMBL |
| PhenoGen | Nek11 | PhenoGen |
| PROSITE | PROTEIN_KINASE_DOM | UniProtKB/TrEMBL |
| PROTEIN_KINASE_ST | UniProtKB/TrEMBL | |
| SMART | S_TKc | UniProtKB/TrEMBL |
| Superfamily-SCOP | Kinase_like | UniProtKB/TrEMBL |
| UniGene | Rn.105331 | ENTREZGENE |
| UniProt | D4A3H8 | ENTREZGENE, UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-11-21 | Nek11 | NIMA-related kinase 11 | Nek11 | NIMA (never in mitosis gene a)- related kinase 11 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-09-25 | Nek11 | NIMA (never in mitosis gene a)- related kinase 11 | Nek11 | NIMA (never in mitosis gene a)-related expressed kinase 11 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-03-06 | Nek11 | NIMA (never in mitosis gene a)-related expressed kinase 11 | Nek11_predicted | NIMA (never in mitosis gene a)- related kinase 11 (predicted) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2005-01-12 | Nek11_predicted | NIMA (never in mitosis gene a)- related kinase 11 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |
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| More on Nek11 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| CRRD Object Information | |
| CRRD ID: | 1308801 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2019-11-27 |
| Status: | ACTIVE |
