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Gene: Rbbp8 (RB binding protein 8, endonuclease) Rattus norvegicus
Symbol: Rbbp8
Name: RB binding protein 8, endonuclease
CRRD ID: 1308872
Description: Predicted to have several functions, including DNA binding activity; RNA polymerase II repressing transcription factor binding activity; and transcription corepressor activity. Involved in response to estradiol. Predicted to localize to nucleoplasm; site of double-strand break; and transcription repressor complex. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; Notch signaling pathway; INTERACTS WITH acetamide; bisphenol A; endosulfan.
Type: protein-coding
Also known as: ctBP-interacting protein; CtIP; DNA endonuclease RBBP8; LOC291787; RBBP-8; retinoblastoma binding protein 8; retinoblastoma-binding protein 8; retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM); sporulation in the absence of SPO11 protein 2 homolog
Homo sapiens (human) : RBBP8 (RB binding protein 8, endonuclease)  HGNC  Alliance
Mus musculus (house mouse) : Rbbp8 (retinoblastoma binding protein 8, endonuclease)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rbbp8 (RB binding protein 8, endonuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : RBBP8 (RB binding protein 8, endonuclease)
Canis lupus familiaris (dog) : RBBP8 (RB binding protein 8, endonuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rbbp8 (RB binding protein 8, endonuclease)
Sus scrofa (pig) : RBBP8 (RB binding protein 8, endonuclease)
Chlorocebus sabaeus (African green monkey) : RBBP8 (RB binding protein 8, endonuclease)
Heterocephalus glaber (naked mole-rat) : Rbbp8 (RB binding protein 8, endonuclease)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0183,134,630 - 3,227,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,162,543 - 3,227,688 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,173,428 - 3,239,961 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,266,565 - 3,333,153 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,269,885 - 3,333,117 (+)NCBI
Celera182,790,129 - 2,855,180 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Rbbp8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308872
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.