Gene: Htra2 (HtrA serine peptidase 2) Rattus norvegicus
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Symbol: Htra2
Name: HtrA serine peptidase 2
Description: Exhibits serine-type peptidase activity; involved in several processes, including aging, ceramide metabolic process, and negative regulation of cell death; localizes to the cytosol and mitochondrion; used to study transient cerebral ischemia; biomarker of asphyxia neonatorum, cryptorchidism, middle cerebral artery infarction, and status epilepticus; orthologous to human HTRA2 (HtrA serine peptidase 2); PARTICIPATES IN intrinsic apoptotic pathway; Parkinson's disease pathway; INTERACTS WITH bisphenol A; clofibric acid; cobalt dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: high temperature requirement protein A2; LOC297376; protease, serine, 25; Prss25; serine protease HTRA2, mitochondrial
Orthologs:
Homo sapiens (human) : HTRA2 (HtrA serine peptidase 2)  HGNC  Alliance
Mus musculus (house mouse) : Htra2 (HtrA serine peptidase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htra2 (HtrA serine peptidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HTRA2 (HtrA serine peptidase 2)
Canis lupus familiaris (dog) : HTRA2 (HtrA serine peptidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htra2 (HtrA serine peptidase 2)
Sus scrofa (pig) : HTRA2 (HtrA serine peptidase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04113,883,671 - 113,886,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04178,568,771 - 178,571,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,262,206 - 117,265,368 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14117,506,685 - 117,509,829 (-)NCBI
Celera4104,551,592 - 104,554,754 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Htra2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1308906
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.