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Gene: Ago3 (argonaute RISC catalytic component 3) Rattus norvegicus
Symbol: Ago3
Name: argonaute RISC catalytic component 3
Description: Predicted to have RNA binding activity and endoribonuclease activity, cleaving miRNA-paired mRNA. Predicted to be involved in several processes, including RNA metabolic process; gene silencing by miRNA; and positive regulation of NIK/NF-kappaB signaling. Predicted to localize to several cellular components, including RISC complex; RISC-loading complex; and nuclear lumen. Orthologous to human AGO3 (argonaute RISC catalytic component 3); PARTICIPATES IN microRNA pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: argonaute 3, RISC catalytic component; Eif2c3; eukaryotic translation initiation factor 2C, 3; LOC313593; protein argonaute-3
Homo sapiens (human) : AGO3 (argonaute RISC catalytic component 3)  HGNC  Alliance
Mus musculus (house mouse) : Ago3 (argonaute RISC catalytic subunit 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ago3 (argonaute RISC catalytic component 3)
Pan paniscus (bonobo/pygmy chimpanzee) : AGO3 (argonaute RISC catalytic component 3)
Canis lupus familiaris (dog) : AGO3 (argonaute RISC catalytic component 3)
Sus scrofa (pig) : AGO3 (argonaute RISC catalytic component 3)
Chlorocebus sabaeus (African green monkey) : AGO3 (argonaute RISC catalytic component 3)
Heterocephalus glaber (naked mole-rat) : Ago3 (argonaute RISC catalytic component 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05144,355,792 - 144,436,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,364,269 - 144,436,509 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,131,514 - 148,203,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,713,438 - 145,779,165 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15145,722,862 - 145,796,791 (-)NCBI
Celera5137,138,867 - 137,210,660 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ago3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309163
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.