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Gene: Spred2 (sprouty-related, EVH1 domain containing 2) Rattus norvegicus
Symbol: Spred2
Name: sprouty-related, EVH1 domain containing 2
Description: Predicted to have protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Predicted to be involved in positive regulation of DNA damage response, signal transduction by p53 class mediator and regulation of protein modification process. Predicted to localize to the cytoplasmic vesicle and plasma membrane. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 17beta-estradiol; all-trans-retinoic acid; bisphenol A.
Type: protein-coding
Also known as: LOC305539; spred-2; sprouty-related, EVH1 domain-containing protein 2
Homo sapiens (human) : SPRED2 (sprouty related EVH1 domain containing 2)  HGNC  Alliance
Mus musculus (house mouse) : Spred2 (sprouty-related EVH1 domain containing 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spred2 (sprouty related EVH1 domain containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SPRED2 (sprouty related EVH1 domain containing 2)
Canis lupus familiaris (dog) : SPRED2 (sprouty related EVH1 domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spred2 (sprouty related EVH1 domain containing 2)
Sus scrofa (pig) : SPRED2 (sprouty related EVH1 domain containing 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.014104,268,362 - 104,290,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014104,002,472 - 104,024,316 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414100,775,869 - 100,797,717 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.114100,717,198 - 100,818,203 (+)NCBI
Celera1493,246,801 - 93,268,145 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Spred2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309304
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.