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Gene: Lrp5 (LDL receptor related protein 5) Rattus norvegicus
Symbol: Lrp5
Name: LDL receptor related protein 5
Description: Predicted to have Wnt-activated receptor activity; Wnt-protein binding activity; and coreceptor activity involved in Wnt signaling pathway. Involved in response to peptide hormone and response to radiation. Predicted to localize to plasma membrane and receptor complex. Used to study autosomal dominant polycystic kidney disease and polycystic liver disease. Biomarker of osteonecrosis; osteoporosis; and tendinitis. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: LOC293649; low density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 5; MGC188568
Homo sapiens (human) : LRP5 (LDL receptor related protein 5)  HGNC  Alliance
Mus musculus (house mouse) : Lrp5 (low density lipoprotein receptor-related protein 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp5 (LDL receptor related protein 5)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP5 (LDL receptor related protein 5)
Canis lupus familiaris (dog) : LRP5 (LDL receptor related protein 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp5 (LDL receptor related protein 5)
Sus scrofa (pig) : LRP5 (LDL receptor related protein 5)
Chlorocebus sabaeus (African green monkey) : LRP5 (LDL receptor related protein 5)
Heterocephalus glaber (naked mole-rat) : Lrp5 (LDL receptor related protein 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Lrp5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309329
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.