Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Crb2 (crumbs cell polarity complex component 2) Rattus norvegicus
Symbol: Crb2
Name: crumbs cell polarity complex component 2
CRRD ID: 1309368
Description: Predicted to have aspartic-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including embryonic morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and maintenance of epithelial cell apical/basal polarity. Predicted to localize to apical plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2); INTERACTS WITH bisphenol A; furan; 1,2-dichloroethane (ortholog).
Type: protein-coding
Also known as: crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2; crumbs homolog 2 (Drosophila); LOC366031; RGD1309368; similar to 5930402A21 protein
Homo sapiens (human) : CRB2 (crumbs cell polarity complex component 2)  HGNC  Alliance
Mus musculus (house mouse) : Crb2 (crumbs family member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crb2 (crumbs cell polarity complex component 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CRB2 (crumbs cell polarity complex component 2)
Canis lupus familiaris (dog) : CRB2 (crumbs cell polarity complex component 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crb2 (crumbs cell polarity complex component 2)
Sus scrofa (pig) : CRB2 (crumbs cell polarity complex component 2)
Chlorocebus sabaeus (African green monkey) : CRB2 (crumbs cell polarity complex component 2)
Heterocephalus glaber (naked mole-rat) : Crb2 (crumbs cell polarity complex component 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0322,037,812 - 22,061,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,038,357 - 22,058,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0327,273,846 - 27,296,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4317,539,288 - 17,559,629 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1317,436,230 - 17,456,001 (+)NCBI
Celera319,976,389 - 19,996,310 (+)NCBICelera
Cytogenetic Map3q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Crb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309368
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.