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Gene: Slc46a1 (solute carrier family 46 member 1) Rattus norvegicus
Symbol: Slc46a1
Name: solute carrier family 46 member 1
Description: Exhibits folic acid transmembrane transporter activity and methotrexate transmembrane transporter activity. Involved in folic acid transport and methotrexate transport. Localizes to brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: heme carrier protein 1; LOC303333; MGC108986; PCFT/HCP1; proton-coupled folate transporter; RGD1309472; similar to DNA segment, Chr 11, ERATO Doi 18, expressed; solute carrier family 46 (folate transporter), member 1; solute carrier family 46, member 1
Homo sapiens (human) : SLC46A1 (solute carrier family 46 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc46a1 (solute carrier family 46, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc46a1 (solute carrier family 46 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC46A1 (solute carrier family 46 member 1)
Canis lupus familiaris (dog) : SLC46A1 (solute carrier family 46 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc46a1 (solute carrier family 46 member 1)
Sus scrofa (pig) : SLC46A1 (solute carrier family 46 member 1)
Chlorocebus sabaeus (African green monkey) : SLC46A1 (solute carrier family 46 member 1)
Heterocephalus glaber (naked mole-rat) : Slc46a1 (solute carrier family 46 member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01065,728,508 - 65,741,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,733,991 - 65,740,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,902,790 - 65,915,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,576,068 - 64,582,504 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11064,589,690 - 64,596,123 (+)NCBI
Celera1062,338,075 - 62,344,511 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Slc46a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309472
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.