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Gene: Kmt2e (lysine methyltransferase 2E) Rattus norvegicus
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Symbol: Kmt2e
Name: lysine methyltransferase 2E
Description: Predicted to have enzyme binding activity and methylated histone binding activity. Predicted to be involved in several processes, including neutrophil activation; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of macromolecule metabolic process. Predicted to localize to the nucleus; protein-containing complex; and transcriptionally active chromatin. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; LOC311968; lysine (K)-specific methyltransferase 2E; Mll5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
Orthologs:
Homo sapiens (human) : KMT2E (lysine methyltransferase 2E)  HGNC  Alliance
Mus musculus (house mouse) : Kmt2e (lysine (K)-specific methyltransferase 2E)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2e (lysine methyltransferase 2E)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2E (lysine methyltransferase 2E)
Canis lupus familiaris (dog) : KMT2E (lysine methyltransferase 2E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2e (lysine methyltransferase 2E)
Sus scrofa (pig) : KMT2E (lysine methyltransferase 2E)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.048,187,751 - 8,255,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.048,193,464 - 8,261,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.447,042,012 - 7,111,851 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.147,042,856 - 7,111,933 (-)NCBI
Celera47,269,290 - 7,338,691 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Kmt2e
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309641
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.