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Gene: Xrn1 (5'-3' exoribonuclease 1) Rattus norvegicus
Symbol: Xrn1
Name: 5'-3' exoribonuclease 1
CRRD ID: 1309713
Description: Predicted to have 5'-3' exoribonuclease activity; G-quadruplex DNA binding activity; and G-quadruplex RNA binding activity. Involved in cellular response to organonitrogen compound; negative regulation of translation; and response to testosterone. Localizes to several cellular components, including P-body; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1); PARTICIPATES IN ribosome biogenesis pathway; RNA degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC300944; RGD1309713; similar to 5-3 exonuclease
Homo sapiens (human) : XRN1 (5'-3' exoribonuclease 1)  HGNC  Alliance
Mus musculus (house mouse) : Xrn1 (5'-3' exoribonuclease 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrn1 (5'-3' exoribonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XRN1 (5'-3' exoribonuclease 1)
Canis lupus familiaris (dog) : XRN1 (5'-3' exoribonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrn1 (5'-3' exoribonuclease 1)
Sus scrofa (pig) : XRN1 (5'-3' exoribonuclease 1)
Chlorocebus sabaeus (African green monkey) : XRN1 (5'-3' exoribonuclease 1)
Heterocephalus glaber (naked mole-rat) : Xrn1 (5'-3' exoribonuclease 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08103,774,125 - 103,883,563 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,774,358 - 103,878,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,224,942 - 103,334,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48101,018,972 - 101,124,770 (+)NCBIRGSC3.4rn4RGSC3.4
Celera895,973,269 - 96,077,718 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Xrn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309713
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.