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Gene: Xrn1 (5'-3' exoribonuclease 1) Rattus norvegicus
Symbol: Xrn1
Name: 5'-3' exoribonuclease 1
Description: Predicted to have 5'-3' exoribonuclease activity; G-quadruplex DNA binding activity; and G-quadruplex RNA binding activity. Involved in cellular response to organonitrogen compound; negative regulation of translation; and response to testosterone. Localizes to several cellular components, including the P-body; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1); PARTICIPATES IN ribosome biogenesis pathway; RNA degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 4-amino-2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC300944; RGD1309713; similar to 5-3 exonuclease
Homo sapiens (human) : XRN1 (5'-3' exoribonuclease 1)  HGNC  Alliance
Mus musculus (house mouse) : Xrn1 (5'-3' exoribonuclease 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrn1 (5'-3' exoribonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XRN1 (5'-3' exoribonuclease 1)
Canis lupus familiaris (dog) : XRN1 (5'-3' exoribonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrn1 (5'-3' exoribonuclease 1)
Sus scrofa (pig) : XRN1 (5'-3' exoribonuclease 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08103,774,125 - 103,883,563 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08103,224,942 - 103,334,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48101,018,972 - 101,124,770 (+)NCBIRGSC3.4rn4RGSC3.4
Celera895,973,269 - 96,077,718 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Xrn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309713
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.