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Gene: Nlrc4 (NLR family, CARD domain containing 4) Rattus norvegicus
Symbol: Nlrc4
Name: NLR family, CARD domain containing 4
Description: Predicted to have ATP binding activity and protein homodimerization activity. Predicted to be involved in several processes, including interleukin-1 beta secretion; pyroptosis; and response to bacterium. Predicted to localize to the IPAF inflammasome complex. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 4. Orthologous to human NLRC4 (NLR family CARD domain containing 4); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Card12; caspase recruitment domain family, member 12; ice protease-activating factor; ipaf; LOC298784; NLR family CARD domain-containing protein 4
Homo sapiens (human) : NLRC4 (NLR family CARD domain containing 4)  HGNC  Alliance
Mus musculus (house mouse) : Nlrc4 (NLR family, CARD domain containing 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrc4 (NLR family CARD domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRC4 (NLR family CARD domain containing 4)
Canis lupus familiaris (dog) : NLRC4 (NLR family CARD domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrc4 (NLR family CARD domain containing 4)
Sus scrofa (pig) : NLRC4 (NLR family CARD domain containing 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0622,167,874 - 22,194,755 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0632,058,459 - 32,081,799 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4620,934,595 - 20,953,654 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1620,933,896 - 20,956,415 (+)NCBI
Celera620,554,800 - 20,577,780 (+)NCBICelera
Cytogenetic Map6q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Nlrc4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309831
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.