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Gene: Irx2 (iroquois homeobox 2) Rattus norvegicus
Symbol: Irx2
Name: iroquois homeobox 2
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; proximal/distal pattern formation involved in metanephric nephron development; and specification of loop of Henle identity. Predicted to localize to nucleus. Orthologous to human IRX2 (iroquois homeobox 2); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Iroquois related homeobox 2; Iroquois related homeobox 2 (Drosophila); Iroquois related homeobox 5; Iroquois related homeobox 5 (Drosophila); iroquois-class homeodomain protein IRX-2; Irx5; LOC306657
Homo sapiens (human) : IRX2 (iroquois homeobox 2)  HGNC  Alliance
Mus musculus (house mouse) : Irx2 (Iroquois homeobox 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irx2 (iroquois homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IRX2 (iroquois homeobox 2)
Canis lupus familiaris (dog) : IRX2 (iroquois homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irx2 (iroquois homeobox 2)
Sus scrofa (pig) : IRX2 (iroquois homeobox 2)
Chlorocebus sabaeus (African green monkey) : IRX2 (iroquois homeobox 2)
Heterocephalus glaber (naked mole-rat) : Irx2 (iroquois homeobox 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0133,270,388 - 33,275,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl133,271,977 - 33,275,540 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0134,682,802 - 34,688,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.417743,534 - 748,950 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.117743,533 - 748,952 (-)NCBI
Celera129,295,635 - 29,301,053 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Irx2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309834
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.